Manuel K Langer
Stillingsbeskrivelse
Mine forskningsinteresser er hovedsakelig rettet mot medisinsk kjemi og derivatisering av biologisk aktive naturstoffer. Jeg har erfaring med utvikling og syntese av nye antimikrobielle forbindelser, med særlig fokus på membranaktive forbindelser. Et annet forskningsområde er utvikling av nye kinasehemmere fra marine naturstoffer for behandling av ulike krefttyper. I det siste har jeg også blitt interessert i utvikling av nye systemer for karbonfangst basert på fangstmidler fremstilt fra biomasse.
Ida Amalie Nystad Reierth,
Yngve Guttormsen,
Jeanette Hammer Andersen,
Espen Holst Hansen,
Ahmed Mossad Abdelhady,
Manuel K Langer
m.fl.:
Investigation of the histone deacetylase inhibitor potential of phorbazole analogues
Manuel K Langer,
Annette Bayer
:
Stereocontrolled and Adaptable Synthesis of (−)-Aspergilone A via the Key Intermediate (+)-Phenol A
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
Susannah von Hofsten,
Manuel K Langer,
Katja Korelin,
Synnøve Norvoll Magnussen,
Dominik Ausbacher,
Trude Anderssen
m.fl.:
Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Francesco Zilioli,
Tor Haug
m.fl.:
A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
Marianne Hagensen Paulsen,
Magnus Engqvist,
Dominik Ausbacher,
Trude Anderssen,
Manuel K- Langer,
Tor Haug
m.fl.:
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
Sundus Akhter,
Bjarte Aarmo Lund,
Aya Ismael,
Manuel K Langer,
Johan Mattias Isaksson,
Tony Christopeit
m.fl.:
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
Manuel K Langer,
Atreyee Halder,
Marius Haugland-Grange,
Annette Bayer
:
TOWARDS THE DEVELOPMENT OF NEW CARBON CAPTURE TECHNOLOGIES
07. januar 2026 ARKIV
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
m.fl.:
Novel synthetic cationic antimicrobial peptides and their potential as antibiofilm agents
2025 ARKIV
Manuel K Langer
:
Marine natural product inspired synthesis of new membranolytic antimicrobial agents.
2025 ARKIV
Manuel K Langer,
Thomas Wirth,
Annette Bayer
:
Total Synthesis of Aspergilone A: Towards The Development Of New Antifouling Agents
2024 ARKIV
Ataur Rahman,
Manuel K Langer,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson,
Morten B. Strøm
m.fl.:
Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
2023 ARKIV
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
m.fl.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023 ARKIV
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
m.fl.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023 ARKIV
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
2023 ARKIV
Manuel K Langer,
Elise Kjørstad
:
Forskere har laget draps-molekyler som tar knekken på bakterier
Manuel K Langer,
Jan Fredrik Frantzen
:
Making antibacterial supermolecules
Manuel K Langer,
Annette Bayer
:
Total synthesis of Aspergilone A in batch and flow - A comparison
2023 ARKIV
Manuel K Langer,
Annette Bayer
:
Marine natural product inspired synthesis towards new antimicrobial and antifouling agents
UiT Norges arktiske universitet 30. august 2022 ARKIV
Susannah von Hofsten,
Marianne Hagensen Paulsen,
Manuel K Langer,
Synnøve Norvoll Magnussen,
Dominik Ausbacher,
Annette Bayer
m.fl.:
A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
2022 ARKIV
Ataur Rahman,
Manuel Karl Langer,
Hymonti Dey,
Jonathan Hira,
Ekaterina Mishchenko,
Annette Bayer
m.fl.:
Novel antimicrobial and biofilm-inhibitors from marine resources
2020 ARKIV
Manuel K Langer,
Annette Bayer
:
Tetrasubstituted barbiturates and hydantoins as potential antibiotics
2020 ARKIV
Manuel K Langer,
Marianne Hagensen Paulsen,
Morten B. Strøm,
Annette Bayer
:
Amphipathic Hydantoins – potent new antibiotics
2019 ARKIV
Manuel K Langer,
Marianne Hagensen Paulsen,
Morten B. Strøm,
Annette Bayer
:
Amphipathic Hydantoins – potential new antibiotics
Mimicing the marine antimicrobials eusynstyelamides
2018 ARKIV
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Forskningsinteresser
- Syntese av amfipatiske antimikrobielle forbindelser
- Tetrasekstituerte hydantoiner og barbitursyre
- Totalsyntese av marine naturstoffer
- Bærekraftig karbonfangst
Undervisning
KJE-1006 - Miljøkjemi
- Laboratorieassistent
FAR-2301 - Legemiddelkjemi og naturstoffkjemi
- Laboratorieassistent