Course code: BIO-2301

General pharmacology and toxicology

Campus
Semester / Year Spring 2009
Credits 10
BIO-2301 General pharmacology and toxicology - 10 ects
The course is administrated by
Faculty of Medicine
Type of course
This course can be taken as a singular course.
Recommended prerequisites
BIO-1001 Cell and molecular biology, KJE-1001 Introduction to chemistry and the chemistry of biology
Course contents
The course will describe how drugs and toxic substances are handled by the body (pharmacokinetics and toxicokinetics and how they affect the organism (pharmacodynamics and toxicodynamics). Also included are how drugs and toxic substances are transported to their sites of action (absorption and distribution), how they work, how they are detoxified (bio-transformed) and removed (eliminated) from the body. Toxic reactions and effects and drug side-affects are discussed. The course also describes the development and evaluation of new drugs, as well as of drugs with an addiction potential . Herbal medicines and Sámi folk medicines are also touched upon.
Objective of the course
The course should give the student a general introduction to pharmacology and toxicology.
Language of instruction and examination
English
Teaching methods
Lectures and a compulsory semester assignment which will need to be approved prior to final exam.
Assessment methods
Written exam (4 hours). Alphabetical grades (A-F)

Coursework requirements
Semester assignment
Date of written examination
11.06.2009 - Examination date is preliminary and may be subject to change. The definitive examination date will be announced on notice boards at the faculties at the beginning of the month of May for the spring semester and the beginning of the month of November for the autumn semester.
Course overlap
BIO-262 General and human toxicology 10
Recommended reading/syllabus
Text book: Levine´s Pharmacology, Drug Actions and Reactions, Seventh edition, Carol T. Walsh, Rochelle D. Schwartz-Bloom, Taylor & Francis. Chapters 1-16, p. 1-454

Topic: How drugs act on the living organism, chapters 1-3. p. 1-54
Topic: General principles of passage of drugs across biologic barriers, chapter 4. p. 55-78
Topic: Absorption, chapter 5. p. 79-111
Topic: Distribution, chapter 6. p. 113-128
Topic: Excretion, chapter 7. p. 129-152
Topic: Biotransformation, chapter 8. p. 153-183
Topic: Dose-response relationships, chapter 9. p. 185-220
Topic: Time- response relationships, chapter 10. p. 221-258
Topic: Variability in response attributable to the biologic system, chapter 11. p. 259-286
Topic: Variability in response attributable to the conditions of administration, chapter 12. p. 287-323
Topic: Drug toxicity/toxicology, chapter 13. p. 325-366
Topic: How drugs alter physiologic function, chapter 14. p. 367-389
Topic: The pharmacological aspects of drug abuse and drug dependence, chapter 15. p. 391-426
Topic: The development and evaluation of new drugs, chapter 16. p. 425-454


Lectures Spring 2009
First attendance: Thursday 8th of January 2009.
Forelesninger See Schedule for more information about the timetable.

F.aman. II Lisbeth Aasmoe
Aman. II Berit Elisabeth Bang
Aina Westrheim Ravna
F.aman. Kurt Kristiansen
Olayiwula Adedotun Adekoya
Prof. Svein Gunvald Dahl
Prof. Georg Bersvein Sager
Mahmud Tareq Hassan Khan

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Responsible unit: Institutt for medisinsk biologi
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Førsteamanuensis
kurt.kristiansen@uit.no
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Seniorrådgiver
karin.eilertsen@uit.no